Our Review article was just published in Trends in Biotechnology: “In vivo translation of DNA origami: a virus-like particle design framework.” Read it online here

DNA origami gives us extraordinary control over nanoscale structure to develop exciting advances in vaccines, therapeutics, and targeted drug delivery.

But translating DNA origami into in vivo applications requires more than building increasingly sophisticated nanostructures. The real challenge is engineering materials that can survive, navigate, and function within complex biological environments.

This review proposes a virus-inspired framework to do just that.

Huge thanks to a great team — Kousha Kamal, Eric Chiu, Ziji Guo, and Kim Tsoi. And here’s a photo from our lunch celebration

Amir, Travis, and Shana’s work, now published in the Journal of the American Chemical Society, showed that PEG grafted oligolysines can stabilize DNA origami while mediating interactions of surface-displayed ligands with cellular receptors. Congratulations team!